Goal: Diagnostic germline RET evaluation is obtainable to all sufferers with a prognosis of medullary thyroid carcinoma (MTC), or different situations related to a number of endocrine neoplasia kind 2 (MEN2) in the UK. Right here we report the expertise of a single centre’s germline RET evaluation over a 21-year interval.

Design: Retrospective case-note assessment PATIENTS: All index sufferers referred to the Exeter Genomics Laboratory for diagnostic germline RET evaluation between 1997 and 2018, and unaffected relations, present process predictive testing.

Measurements: The speed and nature of pathogenic variant detection was recorded, in addition to the indication for testing.

Outcomes: 1,058 index sufferers and 551 unaffected relations have been examined. The general charge of pathogenic variant detection was 10.2% amongst index sufferers, and 29% amongst unaffected relations.

The most common indication was remoted MTC, and amongst the 690 sufferers with remoted MTC, 68 (9.9%) have been discovered to harbour a RET pathogenic variant. Of these with presumed sporadic MTC, 8.5% have been discovered to harbour germline RET pathogenic variants, in contrast with 36.4% of these with a household historical past of MEN2-associated situations. Pathogenic variants have been recognized in 3.6% and 0% of sufferers with remoted phaeochromocytoma and first hyperparathyroidism respectively.

Conclusions: Though the detection charge of RET germline pathogenic variants in sufferers with presumed sporadic MTC was important, the general detection charge in these with MTC was decrease than anticipated on this collection. Advances in RET evaluation in response to stories of latest variants over the past 20 years are prone to have improved the pick-up charge in recent times.

Key phrases: Hyperparathyroidism; A number of Endocrine Neoplasia Sort 2a; A number of Endocrine Neoplasia Sort 2b; Phaeochromocytoma; Proto-oncogene proteins; c-ret; carcinoma; genetic testing; medullary; main.

 

Goniometer base type B5-R, MicroRT compatible
GB-B5-R-40	MiTeGen	40 BASES	EUR 400
Description: Goniometer base type B5-R, MicroRT compatible; package of 40

Goniometer base type B5-R, MicroRT compatible
GB-B5-R-500	MiTeGen	500 BASES	EUR 4442
Description: Goniometer base type B5-R, MicroRT compatible; package of 500

Medium Aperture Assortment Beamline Sample Preparation Kit
BL100-B5-R-A2	MiTeGen	100 MOUNT/BASE ASSEMBLIES	EUR 1497
Description: Medium Aperture Assortment Beamline Sample Preparation Kit; 100 Dual Thickness MicroMounts (25 each of 75, 100, 150and 200 um aperture DT MicroMounts) on standard 18 mm pins,Installed in 100 B5-R bases,Packaged and stored in 5 MiTeGen base holders

Coxsackievirus (B5)
DAG4691	Creative Diagnostics	0.25 mg	Ask for price

Procyanidin B5
TBW01326	ChemNorm	unit	Ask for price

Rat leukotriene B5(LT-B5) ELISA kit
CSB-EQ027966RA-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat leukotriene B5 (LT-B5) in samples from serum, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat leukotriene B5(LT-B5) ELISA kit
1-CSB-EQ027966RA	Cusabio	EUR 964.80 EUR 6118.80 EUR 3244.80	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat leukotriene B5(LT-B5) in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Serpin B5 antibody
70R-50205	Fitzgerald	100 ul	EUR 292.8
Description: Purified Polyclonal Serpin B5 antibody

Serpin B5 antibody
70R-33858	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal Serpin B5 antibody

Gluten Exorphin B5
5-01227	CHI Scientific	4 x 5mg	Ask for price

B5 Receptor Peptide
45-311P	ProSci	0.1 mg	EUR 405.6
Description: B5 Receptor / PCID1 / EIF3M Peptide

Serpin B5 Antibody
34298-100ul	SAB	100ul	EUR 302.4

Serpin B5 Antibody
34298-50ul	SAB	50ul	EUR 224.4

Cytochrome B5 antibody
20R-CG009	Fitzgerald	100 ul	EUR 548.4
Description: Goat polyclonal Cytochrome B5 antibody

Coxsackievirus B5 protein
30-1334	Fitzgerald	100 ug	EUR 477.6
Description: Purified native Coxsackievirus B5 protein (Faulkener Strain)

B5 Receptor Antibody
abx430923-200ul	Abbexa	200 ul	EUR 460.8

Cytochrome b5 Antibody
abx232186-100ug	Abbexa	100 ug	EUR 577.2

Vitamin B5 [HRP]
DAGA-123H	Creative Diagnostics	1mg	EUR 1466.4

Vitamin B5 [KLH]
DAGA-123K	Creative Diagnostics	1mg	EUR 1482

K6H6/B5 cells
C0033002	Addexbio	One Frozen vial	EUR 651.6

Gluten Exorphin B5
H-1666.0025	Bachem	25.0mg	EUR 691.2
Description: Sum Formula: C30H38N6O7; CAS# [68382-18-3]

Gluten Exorphin B5
H-1666.0100	Bachem	100.0mg	EUR 1995.6
Description: Sum Formula: C30H38N6O7; CAS# [68382-18-3]

anti-Cytochrome b5
YF-PA23551	Abfrontier	50 ul	EUR 400.8
Description: Mouse polyclonal to Cytochrome b5

anti-Cytochrome b5
YF-PA11223	Abfrontier	50 ul	EUR 435.6
Description: Mouse polyclonal to Cytochrome b5

Monoclonal Proinsulin Antibody (Clone HPI-B5), Clone: HPI-B5
AMR09558G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human Proinsulin (Clone HPI-B5). The antibodies are raised in Mouse and are from clone HPI-B5. This antibody is applicable in WB and IHC, E

MicroMesh Epoxied Assembly Head Diameter and Mesh Opening 300/25IN1 (in um) Base Style B5
B-M3-300/25IN1-B5	MiTeGen	20 MOUNT/BASE ASSEMBLIES	EUR 249
Description: MicroMesh Epoxied Assembly Head Diameter and Mesh Opening 300/25IN1 (in um) Base Style B5

MicroMesh Epoxied Assembly Head Diameter and Mesh Opening 400/25IN1 (in um) Base Style B5
B-M3-400/25IN1-B5	MiTeGen	20 MOUNT/BASE ASSEMBLIES	EUR 249
Description: MicroMesh Epoxied Assembly Head Diameter and Mesh Opening 400/25IN1 (in um) Base Style B5

MicroMesh Epoxied Assembly Head Diameter and Mesh Opening 400/25IN2 (in um) Base Style B5
B-M3-400/25IN2-B5	MiTeGen	20 MOUNT/BASE ASSEMBLIES	EUR 249
Description: MicroMesh Epoxied Assembly Head Diameter and Mesh Opening 400/25IN2 (in um) Base Style B5

Mounting Medium
4300	Virostat	3 ml	EUR 216.6
Description: This is Mounting medium (non-fading) used for maintaining optimal conditions needed to obtain the maximum fluorescence emission from Fluorescein.

DC MEDIUM
D04-117-10kg	Alphabiosciences	10 kg	EUR 1894.8

DC MEDIUM
D04-117-2kg	Alphabiosciences	2kg	EUR 458.4

DC MEDIUM
D04-117-500g	Alphabiosciences	500 g	EUR 168

Advanced Medium
C0003-04	Addexbio	RT 500 mL Bottle	EUR 123.6

Medium 199
C0012-01	Addexbio	RT 500 mL Bottle	EUR 126

COLIFORM MEDIUM
C03-127-10kg	Alphabiosciences	10 kg	EUR 1588.8

COLIFORM MEDIUM
C03-127-2kg	Alphabiosciences	2kg	EUR 392.4

COLIFORM MEDIUM
C03-127-500g	Alphabiosciences	500 g	EUR 150

Heller's Medium
CP014-010	GenDepot	10X1L	EUR 118.8

Heller's Medium
CP014-500	GenDepot	50L	EUR 151.2

Hoagland's Medium
CP015-010	GenDepot	10X1L	EUR 118.8

Hoagland's Medium
CP015-500	GenDepot	50L	EUR 151.2

A Medium
DJ1018	Bio Basic	100g	EUR 101.76

EC MEDIUM
E05-100-10kg	Alphabiosciences	10 kg	EUR 976.8

EC MEDIUM
E05-100-2Kg	Alphabiosciences	2 Kg	EUR 259.2

EC MEDIUM
E05-100-500g	Alphabiosciences	500 g	EUR 114

NeuroProgenitor Medium
NM42400	Neuromics	125 ml	EUR 364.8

HLP MEDIUM
H08-107-10kg	Alphabiosciences	10 kg	EUR 2733.6

HLP MEDIUM
H08-107-2Kg	Alphabiosciences	2 Kg	EUR 640.8

HLP MEDIUM
H08-107-500g	Alphabiosciences	500 g	EUR 218.4

M9 Medium
SD7024	Bio Basic	250g	EUR 86.1

M9CA Medium
SD7025	Bio Basic	250g	EUR 86.1

YM Medium
SD7031	Bio Basic	250g	EUR 84.54

TYGPN Medium
SD7032	Bio Basic	250g	EUR 84.01

M63 Medium
SD7033	Bio Basic	250g	EUR 86.1

SIM MEDIUM
S19-110-10kg	Alphabiosciences	10 kg	EUR 1225.2

SIM MEDIUM
S19-110-2kg	Alphabiosciences	2kg	EUR 313.2

SIM MEDIUM
S19-110-500g	Alphabiosciences	500 g	EUR 128.4

SOB MEDIUM
S19-124-10kg	Alphabiosciences	10 kg	EUR 1158

SOB MEDIUM
S19-124-2kg	Alphabiosciences	2kg	EUR 298.8

SOB MEDIUM
S19-124-500g	Alphabiosciences	500 g	EUR 124.8

TCBS Medium
MED1188	Scientific Laboratory Supplies	PK10	EUR 7.52

DNase Medium
MED1196	Scientific Laboratory Supplies	PK10	EUR 7.98

OF Medium
MED1664	Scientific Laboratory Supplies	500G	EUR 68.4

Monoclonal GLP-1 Antibody (Clone HGL-B5), Clone: HGL-B5
AMM04792G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human GLP-1 (Clone HGL-B5). The antibodies are raised in Mouse and are from clone HGL-B5. This antibody is applicable in IF, E

Human Cytochrome b5 Antibody
33293-05111	AssayPro	150 ug	EUR 313.2

Serpin B5 Recombinant Protein
92-135	ProSci	0.05 mg	EUR 588.3
Description: Serpin B5 is a secretive protein that belongs to the Serpin (Serine Protease Inhibitor) family and Ov-serpin subfamily. Serpin B5 is expressed in the prostate, testis, intestine, tongue, lung, and thymus. Serpin B5 exhibits no serine protease inhibitory activity. Serpin B5 also functions as tumor suppressor an angiogenesis inhibitor. It has been shown that Serpin B5 blocks the growth, invasion, and metastatic properties of mammary tumors. Furthermore, high expression of Serpin B5 is linked to squamous cell carcinoma in non-small-cell lung cancer.

Serpin B5 Blocking Peptide
20-abx063080	Abbexa	EUR 326.40 EUR 493.20	1 mg 5 mg

Serpin B5 (SERPINB5) Antibody
abx038026-100ug	Abbexa	100 ug	EUR 469.2

Serpin B5 (SERPINB5) Antibody
20-abx001093	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Serpin B5 (SERPINB5) Antibody
20-abx008867	Abbexa	EUR 360.00 EUR 526.80 EUR 226.80	100 ul 200 ul 30 ul

Cytochrome b5 Polyclonal Antibody
ABP51122-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of Cytochrome b5 from Human, Mouse, Rat. This Cytochrome b5 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Cytochrome b5 at AA range: 30-110

Cytochrome b5 Polyclonal Antibody
ABP51122-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of Cytochrome b5 from Human, Mouse, Rat. This Cytochrome b5 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Cytochrome b5 at AA range: 30-110

Cytochrome b5 Polyclonal Antibody
ABP51122-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of Cytochrome b5 from Human, Mouse, Rat. This Cytochrome b5 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Cytochrome b5 at AA range: 30-110

Serpin B5 (SERPINB5) Antibody
20-abx115469	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Serpin B5 (SERPINB5) Antibody
20-abx127043	Abbexa	EUR 493.20 EUR 710.40	100 ul 200 ul

Cytochrome B5 (CYB5) Antibody
20-abx014018	Abbexa	EUR 376.80 EUR 117.60 EUR 477.60 EUR 594.00	100 ug 10 ug 200 ug 300 µg

Serpin B5 (SERPINB5) Antibody
20-abx014060	Abbexa	EUR 376.80 EUR 117.60 EUR 477.60 EUR 594.00	100 ug 10 ug 200 ug 300 µg

Gluten Exorphin B5 Peptide
20-abx265771	Abbexa	EUR 393.60 EUR 594.00 EUR 326.40	10 mg 25 mg 5 mg

Serpin B5 (SERPINB5) Antibody
20-abx321461	Abbexa	EUR 360.00 EUR 292.80	100 ul 50 ul

Serpin B5 (SERPINB5) Antibody
20-abx321596	Abbexa	EUR 360.00 EUR 292.80	100 ul 50 ul

Cytochrome b5 Assay Kit
abx298800-100Assays	Abbexa	100 Assays	EUR 510

Homeobox B5 (HOXB5) Antibody
20-abx325423	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Polyclonal Serpin B5 Antibody
APR05559G	Leading Biology	0.1ml	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Serpin B5 . This antibody is tested and proven to work in the following applications:

Polyclonal anti-Cytochrome b5
Cb5	Detroit R&D	50 uL	EUR 336

Serpin B5 Conjugated Antibody
C34298	SAB	100ul	EUR 476.4

Cytochrome b5 Polyclonal Antibody
ES2121-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against Cytochrome b5 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Cytochrome b5 Polyclonal Antibody
ES2121-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against Cytochrome b5 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Anti-Cytochrome b5 antibody
PAab02186	Lifescience Market	100 ug	EUR 426

anti- Cytochrome b5 antibody
FNab02186	FN Test	100µg	EUR 606.3
Description: Antibody raised against Cytochrome b5

Anti-Cytochrome b5 antibody
STJ92622	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Cytochrome b5.

Human Vitamin B5(VB5)
QY-E05699	Qayee Biotechnology	96T	EUR 433.2

Anti-ARHGEF5 (3A12-B5)
YF-MA16260	Abfrontier	100 ug	EUR 435.6
Description: Mouse monoclonal to ARHGEF5

Inactivated Coxsackievirus B5 Antigen
VAng-Lsx0077-inquire	Creative Biolabs	inquire	Ask for price
Description: Coxsackievirus (B5), natural protein.

Anti-Cytochrome b5 (4C2)
YF-MA10219	Abfrontier	100 ug	EUR 435.6
Description: Mouse monoclonal to Cytochrome b5

Anti-Cytochrome b5 (1A8)
YF-MA10220	Abfrontier	50 ug	EUR 435.6
Description: Mouse monoclonal to Cytochrome b5

Mouse IgG1 Monoclonal Clone: HPI-B5 to Proinsulin (Clone HPI-B5)
3106-100	Biovision	100 ug	EUR 426
Description: This product represents Mouse IgG1 Monoclonal Clone: HPI-B5 against Proinsulin (Clone HPI-B5)for application in Indirect ELISA, Western blot, Immunohistochemistry.The immunogen is Recombinant full length insulin.This antibody can be used for detection of the target molecule in samples from Human, bovine, pig.

MicroMesh Epoxied Assembly Head Diameter and Mesh Opening 300/25IN1 (in um) Base Style B5-R
B-M3-300/25IN1-B5-R	MiTeGen	20 MOUNT/BASE ASSEMBLIES	EUR 339
Description: MicroMesh Epoxied Assembly Head Diameter and Mesh Opening 300/25IN1 (in um) Base Style B5-R

MicroMesh Epoxied Assembly Head Diameter and Mesh Opening 400/25IN1 (in um) Base Style B5-R
B-M3-400/25IN1-B5-R	MiTeGen	20 MOUNT/BASE ASSEMBLIES	EUR 339
Description: MicroMesh Epoxied Assembly Head Diameter and Mesh Opening 400/25IN1 (in um) Base Style B5-R

MicroMesh Epoxied Assembly Head Diameter and Mesh Opening 400/25IN2 (in um) Base Style B5-R
B-M3-400/25IN2-B5-R	MiTeGen	20 MOUNT/BASE ASSEMBLIES	EUR 339
Description: MicroMesh Epoxied Assembly Head Diameter and Mesh Opening 400/25IN2 (in um) Base Style B5-R

Insect Cell Medium: TNM-FH Insect Culture Medium
ABP-MED-10001	Allele Biotech	1 liter	Ask for price

Insect Cell Medium: Serum-Free Insect Culture Medium
ABP-MED-10002	Allele Biotech	1 liter	Ask for price

Insect Cell Medium: Grace?s Insect Medium (Unsupplemented)
ABP-MED-10004	Allele Biotech	1 liter	Ask for price

A-1 MEDIUM
A01-116-10kg	Alphabiosciences	10 kg	EUR 1240.8

A-1 MEDIUM
A01-116-2Kg	Alphabiosciences	2 Kg	EUR 316.8

A-1 MEDIUM
A01-116-500g	Alphabiosciences	500 g	EUR 129.6

Recovery Medium - 6x12mL
1711	Intact Genomics	4/PK	EUR 153.6

Aqueous Mounting Medium
AR1018	BosterBio	10mL X5 (Enough for 800-1200 assays)	EUR 96

Antifade Mounting Medium
AR1109	BosterBio	10mL (for 1000 assays)	EUR 78

MCDB 131 Medium
CM034-050	GenDepot	500ml	EUR 102

MCDB 131 Medium
CM034-300	GenDepot	6x500ml	EUR 198

MCDB 131 Medium
CM034-310	GenDepot	10x500ml	EUR 262.8

MCDB 131 Medium
CM034-320	GenDepot	20x500ml	EUR 408

MCDB 131 Medium
CM034-350	GenDepot	50x500ml	EUR 702

Williams' Medium E
CM063-050	GenDepot	500ml	EUR 109.2

Williams' Medium E
CM063-300	GenDepot	6x500ml	EUR 319.2

Williams' Medium E
CM063-310	GenDepot	10x500ml	EUR 375.6

Williams' Medium E
CM063-320	GenDepot	20x500ml	EUR 724.8

Williams' Medium E
CM063-350	GenDepot	50x500ml	EUR 1170

AddexBio Cryopreservation Medium
C0002-20mL	Addexbio	RT vial	EUR 124.8

CARY & BLAIR MEDIUM
C03-131-10kg	Alphabiosciences	10 kg	EUR 2622

CARY & BLAIR MEDIUM
C03-131-2Kg	Alphabiosciences	2 Kg	EUR 616.8

CARY & BLAIR MEDIUM
C03-131-500g	Alphabiosciences	500 g	EUR 211.2

Cereal Crops Medium
CP003-005	GenDepot	5L	EUR 135.6

Cereal Crops Medium
CP003-010	GenDepot	10X1L	EUR 202.8

Kao Michayluk Medium
CP017-010	GenDepot	10X1L	EUR 118.8

Kao Michayluk Medium
CP017-500	GenDepot	50L	EUR 151.2

Orchid Maintenance Medium
CP037-010	GenDepot	10X1L	EUR 130.8